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Effect of apolipoprotein E and butyrylcholinesterase genotypes on cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease

机译：载脂蛋白E和丁酰胆碱酯酶基因型对阿尔茨海默病不同阶段对胆碱酯酶抑制剂治疗认知反应的影响

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Factors that influence response to drug treatment are of increasing importance. We report an analysis of genetic factors affecting response to cholinesterase inhibitor therapy in 165 subjects with Alzheimer's disease (AD). The presence of apolipoprotein E e4 (APOE e4) allele was associated with early and late cognitive response to cholinesterase inhibitor treatment in mild AD (Mini-Mental State Examination (MMSE) greater than or equal to21) (P

机译：影响对药物治疗反应的因素越来越重要。我们报告了影响阿尔茨海默氏病（AD）165名受试者对胆碱酯酶抑制剂治疗反应的遗传因素分析。载脂蛋白E e4（APOE e4）等位基因的存在与轻度AD（最小精神状态检查（MMSE）大于或等于21）对胆碱酯酶抑制剂治疗的早期和晚期认知反应有关（P

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Patterson, Cathryn; Todd, Stephen; Passmore, Peter;
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年度 2011
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正文语种 eng
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1. Effect of apolipoprotein E and butyrylcholinesterase genotypes on cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease. [J] . Patterson CE, Todd SA, Passmore AP The pharmacogenomics journal . 2011,第6期

机译：载脂蛋白E和丁酰胆碱酯酶基因型对阿尔茨海默氏病不同阶段对胆碱酯酶抑制剂治疗的认知反应的影响。
2. Effect of APOE and CHRNA7 Genotypes on the Cognitive Response to Cholinesterase Inhibitor Treatment at Different Stages of Alzheimer's Disease [J] . Sampaio Braga Ianna Lacerda, Silva Patricia Natalia, Furuya Tatiane Katsue, American journal of Alzheimer's disease and other dementias . 2015,第2期

机译：APOE和CHRNA7基因型对阿尔茨海默氏病不同阶段对胆碱酯酶抑制剂治疗认知反应的影响
3. Butyrylcholinesterase K and Apolipoprotein E-epsilon 4 Reduce the Age of Onset of Alzheimer's Disease, Accelerate Cognitive Decline, and Modulate Donepezil Response in Mild Cognitively Impaired Subjects [J] . De Beaumont Louis, Pelleieux Sandra, Lamarre-Theroux Louise, Journal of Alzheimer's disease: JAD . 2016,第3期

机译：丁酰胆碱酯酶K和载脂蛋白Eε4降低轻度认知障碍受试者的阿尔茨海默氏病发病年龄，加速认知下降并调节多奈哌齐反应
4. Improving adherence and persistence to cholinesterase inhibitor therapy in Alzheimer's disease: development of the CaretoCare? caregiver support program [C] . Brady R., Walburn J., Weinman J., International Conference of Alzheimer's Disease International . 2012

机译：在阿尔茨海默病的胆碱酯酶抑制剂治疗中提高依从性和持续性：Caretocare的发展？护理人员支持计划
5. Synthesis of Bivalent Organothiophosphate Inhibitors and Their Inhibition of Butyrylcholinesterase: Studies towards a Potential Treatment of Cognitive Loss Associated with Alzheimer's Disease [D] . Tahira, Ambreen. 2017

机译：二价有机硫代磷酸酯抑制剂的合成及其对丁酰胆碱酯酶的抑制：潜在治疗与阿尔茨海默氏病相关的认知丧失的研究
6. Progression from Mild Cognitive Impairment to Alzheimers disease: effects of gender butyrylcholinesterase genotype and rivastigmine treatment [O] . Steven Ferris, Agneta Nordberg, Hilkka Soininen, -1

机译：对阿尔茨海默病的轻度认知障碍的进展：性别丁二醇酯酶基因型和菌敏治疗的影响
7. Hippocampal atrophy but not white-matter changes predicts the long-term cognitive response to cholinesterase inhibitors in Alzheimer’s disease [O] . 2015

机译：海马萎缩而非白质改变预示了阿尔茨海默氏病对胆碱酯酶抑制剂的长期认知反应

Effect of apolipoprotein E and butyrylcholinesterase genotypes on cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease

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